What are the symptoms of mixed connective tissue disease?
What are the symptoms of mixed connective tissue disease (MCTD)?
- Muscle pain with no apparent cause.
- Joint pain.
- Low-grade fever.
- Raynaud phenomenon (reduced blood flow to the fingers, toes, ears, and nose, causing sensitivity, numbness, and loss of color in these areas).
What is mixed connective tissue disease life expectancy?
Mixed connective tissue disease (MCTD) is a rare autoimmune disorder. According to the National Institutes of Health, the 10-year survival rate of people MCTD is about 80 percent. That means 80 percent of people with MCTD are still alive 10 years after being diagnosed.
What antibody is associated with mixed connective tissue disease?
Mixed connective-tissue disease (MCTD) was first recognized by Sharp and colleagues (1972) in a group of patients with overlapping clinical features of systemic lupus erythematosus (SLE), scleroderma, and myositis, with the presence of a distinctive antibody against what now is known to be U1-ribonucleoprotein (RNP).
How common is mixed connective tissue disease?
Individuals with mixed connective tissue disease have symptoms that overlap with those of two or more connective tissue diseases. These diseases include systemic lupus erythematosus, polymyositis, scleroderma, and rheumatoid arthritis. It occurs in approximately 90 percent of individuals with MCTD.